Hi! I need more information about what actually happens when you try to run it. Does any window open? Is there an error message?
Also, if it starts but fails to enter the main menu, press Win+R, and paste this in: %USERPROFILE%\AppData\LocalLow\Nifflas' Games\Xenosphere, this should open a folder containing Player.log - if I could get a look at that file, I could maybe figure out what's causing it