The synergies in this game are very fun, ended up winning my first run with Obelisk > Barrier > Volatile sentinel > a filler guy > Dancer that repeats its abily > Imbued wanderer > Sentry gun. Absolutely mulched the dragon!
I love how mechanically straightforward this game is, each unit can get exactly one extra ability. It makes it a lot easier to manage than other higher scale rogues like Isaac or One Step from Eden