Setting up a random dungeon is pretty cool! You can't go wrong with top down dungeon crawlers, I had fun! One thing I would suggest for gameplay. Perhaps shrink the players hitbox a bit. This gives player more time to react and move away from enemies. It also makes it super obvious when you as the player are hit if you don't have any other feedback. It also tends to feel better when you have some lee-way.
A very good idea still! Having a random debuff/curse you need to deal with through the hole game is an interesting concept.