In the game I was playing when I wrote that comment, the "Tactical Systems" technology was a fourth-column technology. I only had "Cannon"s to deal with the threats (no "Ammunition Factory" unlocked, yet), so I was getting hit with a significant number of extra Unwellness and Crisis Points. I managed to win the game once I SLOWLY crawled forward on the technology tree to "Missile Systems" (I think that's the name? Tier 3 building, 7 Combat Points when played), but it took an hour-and-a-half with a lot of very careful thinking on most turns.
Three enemies that each have 7 to 12 hitpoints and cycle their effects every 3 turns is a lot to deal with when I can, at best, manage an average of 3 Combat Points per turn. "Tactical Systems" got this up to around 4 or 5 per turn, but it still had me in a minor panic.
Thinking back on it now that I'm calmer, I'm starting to wonder if "kill everything that isn't a Raider and just manage the unwellness" would have been an easier strategy. :P