They can be used with RMK as custom tilesets with custom tilesizes. RMK uses 48x48, you would either need to use a script for custom tilesizes or to change your tileset config (if you are using MZ) as pointed out here: https://www.reddit.com/r/RPGMaker/comments/1eczik2/how_to_change_tile_size_in_mz/
Regarding the auto-tilling blob placement, you can use LibreSprite (https://libresprite.github.io/#!/) do edit the tilesets. If you need a guide on what to place and where, check these out:
For MV: https://rpgmakerofficial.com/product/MV_Help/page/01_11_01.html#p02 For MZ: https://rpgmakerofficial.com/product/MZ_help-en/01_11_01.html
I might take some time later this week and have these tilesets arranged in a RMK fashion, all that you would need to do is change what is the default size of your tiles :) Keep in mind that would mess up the usage for the default RTP tilesets since mine are 32x32 and RTP is 48x48.