It looks like your savegame file got corrupted. Did the game crash or did you close it (while it saved)? If you want you can send me the savegame file which isn't working at info@stevencolling.com so I can have a look, but it's likely I won't be able to repair/fix it. Big, big sorry! :(
I made multiple new saves and I think the game struggles when I get alot of debuffs. The more I had the slower it ran until it was unplayable and eventually didn't start (The game never fully crashed, it just stoped starting).
Although this is a strong motivator to keep tabs on my stamina and hunger :)
Also great game I really enjoy it and I can't wait until it's released