I am working on an idea that had been bouncing around my head for ages. In the game, you are playing as someone who is trying to balance his social, work, family and love live, and failing at most of them. As you play, you are likely to become more estranged from everyone, and end up cutting ties with them altogether. I'm currently working on a Jenga tower version and one without it, that tweaks a lot of the rules around, but keeps the themes.
The game is called Overcoming Solipsism.