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Nice concept. Definitely fun when the panic sets in and you're trying to find the right combination of effects as the enemies get closer.
I think there could be more clarity about what the different effects do. Sometimes I seemed to get a dud even without a skull selected, and sometimes I had a skull selected, but the gun worked fine. Not sure what the difference was. 

(+1)

Thank you, glad you like it.

You got dud when both in the column and row there are : 

1. two or more skull. 

2. nothing match

For example in the highlighted row, you got Explosive-Skull-Skull. But in the highlighted column, you got Chain-Chain-Slow. Your bullet will produce Chain Lv1 effect. But if the highlighted column you got Chain-Skull-Skull or Chain-Explosive-Slow, your bullet will produce a dud.

I am aware that I need to clarify that and gives the effect of each slot, not just the skull. I just ran out of time to do that. I will focus more on this and the presentation in the next update