What do you mean by "Low res"? PS1 style? Half-life 1 style?
Here is a good tutorial for PS1 style graphics using blender and Godot:
I would start with blender, and then use either Godot or Unity as an engine. You could roll your own engine (what I would do personally), it wouldn't have to be particularly complicated, at least graphics wise, but if this is your first experience making a game, then I wouldn't recommend this.