I really liked it! Reminded me a lot of To The Moon (which is a game I like a lot). I really liked the art (particularly how they changed between ages), I thought the audio worked really well, and I liked the concept overall!
I did end up getting stuck on a level where there were spikes on the bottom level; the ceiling just seemed to short to be able to jump over them and there weren't any rewind clocks to be able to glide as a baby from the potplants. So I died a bunch of times trying to jump the spikes and gave up at that point. But overall I'd liked what I'd played up to that point! (if I missed something then let me know and I'll have another go at that part).
My only problem was the pacing seemed a bit off at times; sometimes I would be super rushed to get the clock and rewind to the appropriate age at the right time (which was fine because that was part of the challenge), but other times I would need to switch to the baby just to crawl under one thing, but then would have to wait for a while to be able to jump over whatever object was in front of me. I guess the hitbox on middle-age Manolo could be a bit bigger too, but that's pretty minor :)
Well done!