This was very cool. I like the idea of crafting your attacks on the fly. I particularly like the simple color combination rules combined with the intuitive status effects that those colors apply.
The fact that your resources respawn instantly makes a really strong emphasis on your click dexterity. If you're an APM god, this game is probably a lot easier. I'm not saying that's good or bad, just pointing it out. If you wanted to deemphasize clicking skill, you could have a resource spawn cooldown to limit how quickly one could click their way through things.
I could see there being a lot of depth in here if you wanted to explore further. Stringing together combo attacks with multiple colors, adding more reactions back and forth between the player and the monsters, etc.
Well done!