On my second fight in 4.3 I had multiple turns where I had to either do a "combo" of one move because I had 2 4s and 2 1s, or I had turns where no offensive option was available to me. That's a very frustrating player experience because, as the one playing a game, surely I should get to choose what happens to at least some degree.
Why are you so married to the idea of making combos out of random cards? It's an inherently flawed system because the player never has any real control or ability to plan their next turn.