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Will you be making at least one girl who is into the MC having a higher estrogen, or will there only be hetero relationships available? Also, do estrogen and testosterone affect each other? ( Such as, if I get +2 estrogen do I also get -2 testosterone, or can both be in the + at the same time?)

Sorry, no girls for estrogen characters. Technically they do not affect each other, but usually whatever raises one lowers the other.