Sorry to hear of your technical woes with the game. Could you let us know what OS you are running? I'll need to gather as much information as possible to address this crash and other bugs you've reported so we can get them fixed for the next build!
One thing I'd try to verify is that your controls are actually set to keyboard and mouse in the game menu. Another problem I've had is if I try to use keyboard shortcuts to enable fullscreen/windowed mode. Make sure to set all of that in the ESC menu options.
These crash and bug reports are incredibly helpful to us so please do keep sending them in. I'll try to keep a thread open specifically for bug reporting.
Thanks again!