Earnest gratitude for this response. It helps you seem to get me.
Different bosses for different ways of leaving would be very (in the true sense of the adverb) engaging, if pulled off right. I can imagine some anti-Juice-Queen resistance fighter, for example, being a foe if we choose to stick with Mrs. Slitherss.
I am ethically obliged to concede, though, that if we could be so lucky, then with both options on the table, some other bosses are only accessible if you bail out on Mrs. Slitherss the current way. Not necessarily any of the ones we currently have (as of 0.1.8), except perhaps but later ones that Fishlicka may add in the future. Even dropouts deserve something to make them shut up, those mooching punks love.
On which note, for the boss fight against Mrs. S: Even Mrs. Slitherss herself could turn on us anyway if we go with her, but much, much later if we went with her at first. She could be tougher in this case.