There's an issue when I run under WINE on Linux that the UI becomes unresponsive if you switch window focus to something else. Don't know what causes it or if it affects other people, but I remember I had the same problem with Oxygen Not Included (when running via WINE and not natively)
Viewing post in SALVO jam comments
By the way I figured out the workaround for the unity games that have this problem, you can set WINE to emulate a virtual desktop, which fixes some focus issues or something. I can pretend I'm playing windowed if I set the game to fullscreen since then it just takes up the window for the virtual desktop.
Found this out while trying to pirate rimworld, then I pulled an all-nighter+ and forgot about my stream slot