Hey hey! Yeah, I was beginning to get pretty frustrated with all the issues Tyrano had that just weren't getting fixed by the engine devs after years. They actually released a huge update for Tyrano recently, which really shocked me because I thought it was dead support-wise! It looks like a decent update, but I doubt I'll be using it again.
I found Unity (specifically using Naninovel) a much smoother experience for creating than Tyrano by a long shot. It was so easy to pick up! I would absolutely recommend Unity with Nani over Tyrano any day. But over Ren'Py? I'm not so certain there. I feel like a lot of the games I've played that were made with Ren'Py are really smooth and I love the default sorta UI setup. I'm still kinda wrestling with Unity's UI and find it a bit of a nightmare to deal with, haha.
I haven't released any games made with Ren'Py, but I did start learning how to make stuff using it before I bought Tyrano on sale. From what I learned back then, I thought Ren'Py was fantastic. I only checked out Tyrano because I thought it might save time over learning Python. I do regret that decision now though because while Tyrano was super easy to get to grips with, I feel like the visual system really slows down the pace of development as opposed to typing everything up in Visual Studio Code like I do now.
If you're already very comfortable with Ren'Py, I'd say that maybe it's not worth switching to anything else. But I do highly recommend Naninovel despite that. It's very easy to use + the creator is constantly updating it with new features that the community requests, so the overall support for it is fantastic.
Sorry if I wasn't all that helpful >.< It's hard to give a good answer when I'm not overly familiar with using Ren'Py. It's just, from the little time I spent using it + the games I've played made with it, it seems to me like the best option around still considering it's completely free. If you do decide to check out Nani, it does go on sale on the Unity asset store quite often. I got it at 75% discount in the winter sale. There's no way I could afford it at full price >.<