This one's incredibly charming! The theme of "One Room" is demonstrated in its most creative expression I've seen yet!
I think from a balance perspective, you could potentially lower the move-speed of some enemies to allow a bit more time reacting to them, or widen the buttons to ensure that quick reactions won't miss as much. I found myself one pixel off the jump sometimes, and that's all it takes to end my stridin'.
That said, the aesthetic, both audio and visual, are very well realized, and the voice acting adds a layer of polish as well.
Yee-haw!