Love the game so far, got a few problems with the trade routes in 2.4.5, both of these were found on small worlds.
First I settled in an area where half the area was connected to a large continent and the other half was cut off and surrounded by sea, even though I had the mansion on the main landmass no land trade routes could connect to the settlement, which made my plans of having it be an incredibly safe trade hub disappear.
The next problem was on a sea trade route down a river, I notices the ships were being attacked when they moved alongside the mainland so I went to add way points so they stayed safe, I placed a point down right in front of the dock I was using and the route disappeared with my ships not trading with the settlement anymore, even deleting the trade route didn't fix the problem.