Always impressive to see a card game made in RPG Maker, with an awesome dark fantasy art style!
The isometric map exploration is definitely a cool feature, and the other comments have discussed possible options to help with navigation.
UI-wise, some areas feel a little clunky. Needing to scroll through empty hand slots when selecting cards in your hand adds unnecessary button presses. I found the system to equip/unequip cards tricky to keep track of when they are all in the same list, and it forces you out of the menu whenever changes are made.
Cool to see this new iteration of your card system!