It depends on each build. Usually no, however I'll be adding a quest log in an upcoming build which will crash the game unless it's a fresh save created from build 0.6 or later. When this happens I usually provide a semi-complete save file that can get passed around to use. You can change the MC's name in the Bunny Manor as well.
Viewing post in game updates do we have to restart the game
speaking of update, I notice in this latest build, Leslie during movie night has a dialog error. I know she is intended to be a milf character but if we go with the default roles where she is the maid, she has the line "I can't believe I'm fitting my own Son's cock in my mouth!" So does she have specific lines for different scripted roles?