Hi,
This is a really fun idea and concept. The setting is something which is easily imagined and populated. I share the same feeling as Danny Wall that it is missing some kind of obstacle/conflict examples or generators. I would love to know what ideas you have for them.
The O&O mechanic is fun and I like how friends can help each other out narratively with it.
I love the artwork of the blobby amoebas and their details. I think it would be helpful for a reader if the middle portions of the text (How to play, Stats and Character Creation) were laid out from left to right because how they rely on each other for comprehension. I think a less weighty body font would help readability and the look. : )
I am interested to see what you would create next!
-Vish