Oh, thanks!! Unfortunately, A Crimp in Time wasn't built on my computer but another dev on the jam team that I was on. I just did audio programming and music/sfx for that. I have built games via Unity on my macOS and still get those weird security precautions. Actually, your game here does too. I can still "Open Anyway" from the security menu, but it doesn't let me open it the traditional way. I've noticed that if you download the Itch.io app and start games from there, almost all of those issues go away.
Ah I see. Yeah building from a mac, or running that command and then uploading the build will only solve users having to run the command themselves, but yeah, the security thing I believe can only be resolved by signing the app through Apple which... no thanks. Good to know that running it through Itch.io desktop app fixes the problem, though! Good tip :D