Thank you, i've been looking into it and so far it's caused by a sort of restriction of where programs can save files, hopefully that's all to it (still it might take a while to get it work)
(the remake (https://mutantleg.itch.io/lab-v30) or the original?)
Edit:
I have trouble reproducing it for some reason (tried standard user in Win10 and worked, tried on another pc with Win7 both standard and guest user and neither had trouble starting)
so I need a bit more info about your setup: just simple things like what version of windows you are using, if there any antivirus installed that might be the cause, is the itchi.io app is installed and has the same problems etc.