Very nice pixel art! I would suggest including controls at the start of your game for new players even if they were basic. The movement for the player was a bit sluggish especially outside. Maybe a run option to speed up? It could also have some kind of impact on your overall Headache meter. The player sprite also jitters when moving diagonally.
I like the overall theme of going outside and doing activities to cure a late night gaming session hangover. I do really enjoy taking walks myself when I'm feeling crummy. The only option in the game right now seems to be fishing and there is very little interaction. A few additional activities with additional gameplay mechanics or minigames would be interesting.
Also being killed by the car felt really out of place given the overall tone and aesthetic. The "music" that plays is very grating and nightmarish!
The overall execution could use some work but I really like the approach you took to the theme!