If you were zoomed in / relying entirely on the automatic camera / especially if your screen is small that's likely. It's definitely a problem for smaller screen sizes -- I've made sure the game works but the GUI ends up taking a lot of screen space in that case. You can't click past the GUI because you'd accidentally take turns trying to drag the abilities or interact with the GUI.
But (at least in the first 'stage area' of the game) you go downwards a lot so downwards visibility is important despite me putting GUI in the way down there. I'd like as much open space as possible without the player having to zoom out so they can't even see anything properly (and limited zoom out at 2x zoom out). Maybe I'll make it so the middle mouse button also toggles in and out the GUI, but I still need to think about freeing space. Maybe the top GUI only shows when you get a message and then scrolls out of the way until the player manually brings it down, maybe the bottom GUI only shows if you move your mouse to the bottom of the screen (or a setting can make it always-on) though it'd be annoying if you try to move and the GUI suddenly pops up. I'll give it some thought, thanks.