I'm on a Dell e7440 laptop with Intel Integrated HD 4400 GPU and my drivers are up to date. The game only seems to ever take up about 30-40% of my GPU.
Also thanks for being so responsive! It's good to see your committed to this. I'm happy you're still working on it because I really love the gameplay. You differentiate from classic roguelikes in that the focus is entirely on alchemy (which I love) but the core feeling of game knowledge and preparedness being your best assets is still there. Keep up the great work!
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Sadly, I haven't found anything conclusive. Seems that it really is a hardware compatibility issue. I will add some troubleshooting options to the next release that would allow disabling individual graphical features, and, hopefully, disabling coloring shader for the map will solve the issue.
Also (irrelevant for the issue itself but might be useful) can't help but notice that you seem to be using Windows display scaling. You might want to disable it for the game (in compatibility settings), and readjust the tile size in options (64 is the original size), this way they will look less blurry.
By the way, I just had a thought. If you're willing to experiment some more, would you mind contacting me via email? spellsweaver@gmail.com