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Yah, I too use Windows 10. For me, drag-and-drop is also king. But I'm sure a lot of users naturally use "Ctrl + C" and "Ctrl + P", oh oh and not to forget "Windows Key + V" too (at least for Windows users).

Also have a think about multi-file copy/paste. Some users might want them in the same layer stacked on-top of each other, others would prefer the images tiled, whilst some might want each dragged/pasted image placed onto a new layer per image. Would be great to have these configurable in a Behaviour Questionnaire that pops-up during the multi-image paste action, and be set to a certain behaviour for the session too (and configured by app options)

Hey, yes. But I'm not sure I can handle multi file copy/paste, it's for copy/paste an image not a file.

I'm not even sure it's possible to copy paste the files, I don't think that even Aseprite handle it.