Well... no spoilers :P
But I can say that the question if you can - or should, or want to - return Chloe and Gwen back to "normal" is going to play a large part in their storylines.
I would want to turn them back, as long as Chloe doesn't go fucking berserk on me afterwards.
And I don't want to turn them back ... but then I play pretty evil so yeah..