Did you play in the browser window? Our game is aimed to be played in fullscreen. I've tested the game on 2560x1440 screen all the time and if the game is fullscreen I don't have any problem targeting or placing the bricks.
But like you said, you have problem targeting because the bricks seem small, and you're not the only one. The way we could address this problem is to make first city from larger bricks and gradually make houses from smaller bricks. This way you'll be acclimated to the game mechanics when the difficulty level is where we want it.