Try to first pass all stages With producing hearts and picking useful babies/items for no heart play. When you beat third boss and there starts second loop(first levels again), it's easier to play with collected items and proper babies for your strategy. Basically, you don't have to pass all 3 arcs without chads from the start, you just need to pass them, so even if no-heart after 3 or 4 loops to get all you want, it's fine.