Hi darkempathy, thanks so much for the feedback and I'm glad you liked the game! I'm a sucker for Anne McCaffrey, particularly the Crystal Singer and the Brain and Brawn series - I'm pretty sure Esra was inspired by a twelve year old me sitting and reading about Helva. I was actively thinking about Hypatia from the Ship Who Searched for one of the X'irii ends, and also for some potential future content.
The buttons were something I rushed a fix for last night, so hopefully those work with NVDA now! I'll also look into the non-subdue and popup issues ASAP.
On a side note, I have been watching that audiogames thread and taking notes, particularly with New Game+. I set it to keep levels and upgrades, but either this was a mistake, or difficulty needs to be scaled up with replay in a Borderlands-like style (the second being far more work). I'd recommend keeping a save game taken on the ending screen (ideally save to file as this doesn't rely on browser memory) so if I do release a change to New Game+, it won't involve playing through the too easy version.
When I released the game I genuinely thought one, maybe two, people would play it, so I didn't put NG+ too much in scope. Now it seems people like it, so things like chain events and replayability are on my radar!
If you come across anything else you think would make the game better, let me know. I'm aware there are a limited number of accessible games out there, so anything I can do to polish this one up is a plus.