And I tried to create a .txt file with the text being
[game] modules=core
saved as the file name desolate.conf (and I also tried desolate.cnf) saved in the same directory, but neither of those worked. This is where an in-game module selection would be handy.
Also, I believe the SSRI card is not working: if you have that item, and type :u or otherwise look for a way to remove an affliction, it never gives you the option to use an SSRI.