Common softlock. Enemies with constant defence, constant heal, or constant Dodge <armadillo, sage, cultist> can, and will outramp their defence compared to your offence.
One constant way to beat them is to have at least 2poison damage per turn. At certain point you WILL stack that poison higher than their max HP.
Other way, working on Non-Cultist, is stopwatch or whetstone. You can, and will get more damage than they can defend for. Each use of whetstone is at least +9 allout damage. More if you got bonus energy.