Ok, I have just tested it, if you want to avoid the save glitch, where your inventory gets permanently distorted even if it was ok when you saved it you need to first save when there are no floating items/open menus/map/etc open and just in your inventory menu, make shure to close all of the menus before saving. Also when loading the game remove your mouse from screen the moment you click continue. All of these dont guarantee that it wont occur but it reduces the chances a lot. It still happens sparcely even if you dont do any of this but if you save/load often or dont want to take chances to loose your run these should help. I have just saved/loaded 50 times and it only happened 2 times by the end and it wasnt permanent.