Yes. You can upscale the resolution, but the pixel of the screen must then be upscaled
For example, this screen is 320x288, but the individual pixel of the screen are upscaled by a factor of two (making them 2x2) for a resolution of 160x144.
I see. I'm glad I asked then, because I wasn't planning on blowing it up, just stretching the 160x144 to fit in like an 800x600 window.