Ou.. shoot.. I thought i'd specify that in order to run the game you need to drag&drop the .tqi file from the game folder to the TextQuestInter.exe
Hmmm. I'm not really sure what could get wrong, 'cause it's working on my windows 10 machine. Although, if you have an AMD videocard there could be a problem with the shader loading. Could you please check the log file (located in your game folder in the log subfolder), if one was generated. Maybe it will shed some light on this.