Practically, yes. You can't change your choice after you choose in nameless event. Because the choice you choose has been save into persistent file. If you want to re-choose again, you need to have a previous persistent file (one before you choose a choice.)
I'm not actually sure what a different of each choices and how different path we'll get in a future update, but for sure some choice affect to Nameless's trust.
'persistent' file is exist in 2 folders
1) %appdata%/renpy/lustfuldesire...
2) in your game folder, there is a folder name 'game' in this folder has a folder name 'save' and this save folder has another one persistent file
a file name 'persistent' must be exist in those two folders among all of your save files. You must understand that persistent file ≠ save file and persistent file is a very important file. If you lose this file, your game may occur some bug.
