I am a little confused by what you mean. But as long as the game has a male playable with romanceable heroines, has no adult content, and has a minimum of two endings, then anything is fine. If you are asking if you are able to make an RPG game with the ability to romance, that is totally acceptable. ^^
EDIT: I just realized taking into account your examples, are you asking if you can submit a game that has the option of playing male or female, and is basically a bishoujo game when male and an otome when female? If so, I see no issue with it. So long as you can play a male MC with romanceable females, I see no problem with the available option to play in reverse. ^^