I have to admit I was a bit scared by the introduction/tutorial. There's a lot to take in in pure text and it's hard to remember all the constraints.
I'm really glad I stuck around to give the actual game a go. Everything started clicking after 2-3 rounds of the Alchemist walking their round and I found myself enjoying picking out which cards to place where.
Since there are several constraints to balance, I think having a little tooltip when the player hovers the toxicity, radioactivity etc to explain that particular constraint.
Very cool submission, impressive what you put together in 48h.