Not sure if related to your subject, but like 80~90% of the visual novels from Itchio seem to be built on Ren'py
A iconic exception would be pure pixelated games (where you move your character across a Town or Dungeon)
Still, there are so few Visual Novels centered around the concept of stats, choices and sometimes consequences, I love all these together, especially with a pitch of "bad endings" (resulted of bad choices)
For example, Roommates is based on college season, so is it possible to be kicked out of it if you fail your grades/don't study? Is it possible to seriously end up on bad terms with someone? Etc... Et caetera :)