The problem is discussed, with a possible soluition, in this threat: https://forums.rpgmakerweb.com/index.php?threads/mv-profile-error-occurred-durin...
"It means that at some point you or other users of your computer have installed/downloaded and launched a higher version of NWjs than RPG maker MV uses. It's a completely irrelevant message though and nothing bad happens, since for important settings there is a package.json file inside the folder."
Does the same error message appear when you can't save? Because usually it only appears at the start and can be ignored.Maybe your game is on a read-only / write-protected location or USB stick where the game is not allowed to create save files by the system?