The scroll wheel was definitely a bit of a slog, and I get the frustration because I’ve worked on games with scroll wheel mechanics and mice never seem to line up on different setups. I got around that by taking the friction off my mouse wheel, though, since I have a button for it.
My other issue was with the screen area, and relatedly, the mouse-based panning. I think variable zoom would have helped there. I didn’t love the feel of the mouse pan either, but I don’t have any concrete feedback there (I haven’t worked with them before so I don’t know what knobs are available to tweak).