It's dependent on the major choice, but nothing too negative, as this is a harem game.
Feeding Zara's addiction might lead to a sex scene with Alina - going the other route might lead to a sex scene with Gigi. Both of these would be without Zara present.
^ That's not a real example, but the major choices will sometimes lead to different content with other girls, just nothing majorly negative. The game's overall direction will always be to have sex with all the women all the time.