Am new to Amiga emulation. Using the FS-UAE emulator. Do I need to change any settings?
Well, Amiga emulation is a complex thing as Amigas themselves cover a range of hardware and configurations. Ideally, you would set the emulator up as an A1200 with a fast CPU, 2MB of chip RAM, 4MB of fast RAM, and you'd need to have Amiga OS already installed and working to play the game since it's not in floppy disk image format. That can be a bit overwhelming if you're not already familiar with the Amiga ecosystem, so I'd maybe suggest finding a preconfigured hard drive image.
An alternative option is AmigaLive, which is a preconfigured bundle including FS-UAE that's set up for playing online but can also play single-player games. WeegieNights has just been added to the AmigaLive bundle I believe (in the Blitz Basic Game Jam 2022 bundle), so it might be the simplest way to get started.