When characters receive new story events, they are after the previous events, so no you're fine.
Runey has remade some early events, but those are more for upping quality and rewriting dialogue he feels isn't his best, etc.
The only "missing out" is the new early game explore content - you can absolutely still play it on a later save, but it will feel off chronologically (eg characters who know you acting as though they don't), because it was specifically made to make the early game more active.