Icons make UI more readable, the seals with the separation for the cost is also easier to read now. The vertical menu quick slots is new to me, I think it's an improvement.
Progression felt like last time until BabySteps++ which felt like a bigger jump and I had to retry several times before getting a winning run, I also got lost several times due to my poor inner compass.
A random thought that came to mind, maybe add a mini map that fills as you enter rooms as an easy mode? That would solve some people's being lost issues, though it may go against how you want the game played too much.
Can't think of anything else, keep up the good work goblin dev.