The thing that I regret the most is not having enough time to do some serious game balancing! It was hard to strike a balance between “too easy” and “frequent deaths to one-shots”. I think I ended up a bit closer to the latter, but it’s definitely possible to mostly get a handle on the RNG and avoid the worst of it. Except with the blessings: you can’t replace them and are stuck with what you choose, so if you get bad luck on the RNG there they can really end your run.
There’s a few essential mods (getting enough healing is definitely essential), a pretty big pool of useful mods, and some mods that sound good but should be avoided (and some that are potentially run-ending). I had a lot of fun playing through when developing and discovering the different synergies, and I can confirm that the game is beatable :)