The game is designed to run from a cartridge, so it wouldn't be possible. It's not the size that's the issue, but speed. The game relies on being able to access data from a cartridge immediately.
Viewing post in Briley Witch Chronicles (C64) comments
Just a last question: do you know if is there any hardware project that allows to make a single cartridge for Briley (instead of Kung Fu etc.)?
I mean: (e)eprom based cartridge.
There are some projects on github (like MagicDesk based cartridge with 1 Mb of "storage": https://github.com/msolajic/c64-magic-desk-1024k) that sound interesting, but I'm not sure if Briley would work.
I know that Kung Fu etc. are a modern and easier way to do, but I love the feeling of hard-coded cartridge, one game per cartridge...