I want to start by saying that I would absolutely play the hell out of this game. I’m always a big fan of any game where you trick out your equipment with cool guns and use them to strategically blast the crap out of enemies.
To me, your genre description didn’t make sense. When you talk about going from location to location on a map, upgrading between locations, and using your upgrades to fight off enemies, my first thought is "roguelike," especially that this sounds similar to FTL or Convoy. Now, to be clear, a game like FTL and Convoy is totally an autobuy for me. But it's not a new genre, and it feels coy that you didn't mention that term anywhere. Tower defense seems like another obvious genre that I’m surprised you didn’t mention. On the other hand, you do mention several genres that don’t seem closely related at all, like RTS and RPG.
I was also a little unclear on how the structure of the battles actually functions. Are the enemies trying to attack you, or are you trying to prevent them from getting past you to another objective? What’s the win condition? Destroy a certain number of enemies, survive a certain amount of time, collect a certain amount of resources?
Otherwise I thought the game description was solid; the aliens sounded interesting and I liked the NPCs. But I would qualify this as a fun new game in the vein of FTL, rather than a new genre.